Formulation and quality consideration of cannabidiol printed forms produced by fused-deposition modeling

[Display omitted] •Cannabidiol shows many therapeutic promises, but has poor oral bioavailability and a dose-dependent therapeutic effect.•Amorphous solid dispersions are able to enhance the apparent aqueous solubility and dissolution rate of cannabidiol.•FDM is suitable to shape amorphous solid dis...

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Bibliographic Details
Published inJournal of drug delivery science and technology Vol. 87; p. 104837
Main Authors Jennotte, Olivier, Koch, Nathan, Lechanteur, Anna, Evrard, Brigitte
Format Journal Article Web Resource
LanguageEnglish
Published Elsevier B.V 01.09.2023
Elsevier BV
Subjects
Human health sciences
Pharmaceutical Science
Pharmacie, pharmacologie & toxicologie
Pharmacy, pharmacology & toxicology
Sciences de la santé humaine
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Summary:[Display omitted] •Cannabidiol shows many therapeutic promises, but has poor oral bioavailability and a dose-dependent therapeutic effect.•Amorphous solid dispersions are able to enhance the apparent aqueous solubility and dissolution rate of cannabidiol.•FDM is suitable to shape amorphous solid dispersions produced by HME with different shapes and dosages.•FDMallows the manufacture of oral solid dosages that comply with the European Pharmacopoeia.
Bibliography:scopus-id:2-s2.0-85167624676
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104837