Zebrafish based strategy for the identification of a potential pharmacophore for apoptosis: a greener CuAAC approach for novel 1,2,3-triazoles derived from mefenamic acid

Prompted by the potential of a screening strategy in zebrafish for the identification of valuable pharmacophores, a series of triazole substituted mefenamic acid derivatives were designed and synthesized viaa CuAAC under green conditions. A variety of terminal alkynes were reacted with the azide obt...

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Bibliographic Details
Published inRSC advances Vol. 4; no. 10; pp. 4878 - 4882
Main Authors Babu, PVijaya, Mukherjee, Soumita, Gorja, Dhilli Rao, Yellanki, Swapna, Medisetti, Raghavender, Kulkarni, Pushkar, Mukkanti, K, Pal, Manojit
Format Journal Article
LanguageEnglish
Published 01.01.2014
Subjects
Alkynes
Apoptosis
Danio rerio
Derivatives
Embryos
Freshwater
Strategy
Terminals
Triazoles
Zebrafish
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Summary:Prompted by the potential of a screening strategy in zebrafish for the identification of valuable pharmacophores, a series of triazole substituted mefenamic acid derivatives were designed and synthesized viaa CuAAC under green conditions. A variety of terminal alkynes were reacted with the azide obtained from mefenamic acid to give the expected products in good to excellent yields. When screened for apoptosis, teratogenicity and hepatotoxicity in zebrafish embryos, one of these compounds showed encouraging apoptotic properties and safety profiles and seemed to have medicinal value.
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ISSN:2046-2069
2046-2069
DOI:10.1039/c3ra46185h