Hydrodynamic injection for microchip electrophoresis: Development of an innovative passive system

The world is facing challenges in terms of environmental sustainability and rising costs. In this context, miniaturized equipment such as microfluidic devices can be used to manipulate small volumes of fluids in micrometer-sized channels incorporating multiple components such as pumps, valves and mi...

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Bibliographic Details
Published inGreen Analytical Chemistry Vol. 10; p. 100141
Main Authors Dispas, Amandine, Emonts, Paul, Vandormael, Denis, Bernier, Damien, Dortu, Fabian, Ziemons, Eric, Hubert, Philippe, Crommen, Jacques, Fillet, Marianne
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2024
Elsevier
Subjects
Capillary valve
Hydrodynamic injection
Laser induced fluorescence
Microchip electrophoresis
Synthetic cathinones
Hydrodynamic injection
Synthetic cathinones
Microchip electrophoresis
Capillary valve
Laser induced fluorescence
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Summary:The world is facing challenges in terms of environmental sustainability and rising costs. In this context, miniaturized equipment such as microfluidic devices can be used to manipulate small volumes of fluids in micrometer-sized channels incorporating multiple components such as pumps, valves and mixers. Due to their high flexibility, these devices can provide sustainable alternatives to traditional platforms. The present study focuses on the design of a user-friendly and reliable microfluidic capillary electrophoresis chip for pharmaceutical applications. To meet pharmaceutical requirements in terms of quantification performance and overcome the injection variability usually observed with such microfluidic systems, a reliable and reproducible design for hydrodynamic injection using passive valves has been developed. It has been successfully used for synthetic cathinone analysis.
ISSN:2772-5774
2772-5774
DOI:10.1016/j.greeac.2024.100141