Alokicenones A-H, eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp. HN-A101

Alokicenones A-H (1–8), eight new tetrahydroanthracenes and one known okicenone (9) were identified from the secondary metabolites of mangrove-derived Streptomyces sp. HN-A101. Their structures were elucidated by HRESIMS and NMR spectroscopic data. The absolute configurations of them were determined...

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Bibliographic Details
Published inTetrahedron Vol. 74; no. 46; pp. 6667 - 6672
Main Authors Zhang, Dashan, Jiang, Yongjun, Li, Jiaqi, Zhang, Haojian, Ding, Wanjing, Ma, Zhongjun
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.11.2018
Elsevier
Subjects
Alokicenones A-H
BRD4 inhibitory activities
Chemistry
Chemistry, Organic
Cytotoxicity
Mangrove-derived Streptomyces
Physical Sciences
ROCK2 inhibitory activities
Science & Technology
Mangrove-derived Streptomyces
Cytotoxicity
ROCK2 inhibitory activities
BRD4 inhibitory activities
Alokicenones A-H
SOILS
DISCOVERY
BROMODOMAINS
TARGETS
DERIVATIVES
ALOE
CONSTITUENTS
HAW
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Summary:Alokicenones A-H (1–8), eight new tetrahydroanthracenes and one known okicenone (9) were identified from the secondary metabolites of mangrove-derived Streptomyces sp. HN-A101. Their structures were elucidated by HRESIMS and NMR spectroscopic data. The absolute configurations of them were determined by the calculated and experimental ECD curves. Compounds 1–2 and 9 showed moderate cytotoxicity against HCT116 and SW620 cancer cell lines with IC50 values from 0.63 to 7.73 μM. In addition, compounds 1–3 and 7–9 also exhibited inhibitory activities against ROCK2 or BRD4. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2018.09.049