Chemical constituents from the pericarps of Zanthoxylum bungeanum Maxim. and their chemotaxonomic significance

• Published in: Biochemical systematics and ecology Vol. 119; p. 104941
• Main Authors: Ma, Di-Wei, Mohamed, Khalid Hassan, Hu, Jian-Lin, Yin, Chang-Qin, Wei, Yu-Bin, Chai, Xiao-Pan, Zhang, Qing-Bao, Zhang, Lan-Chun, Liu, Jia, Yu, Hao-Fei
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2025
• Subjects: Alkylamines; Antimicrobial activity; Chemotaxonomy; Flavonoids; Lignans; Zanthoxylum bungeanum; Chemotaxonomy; Flavonoids; Antimicrobial activity; Zanthoxylum bungeanum; Alkylamines; Lignans
• ISSN: 0305-1978
• DOI: 10.1016/j.bse.2024.104941

The phytochemical investigation of the dry pericarps of Zanthoxylum bungeanum Maxim. led to the isolation of 24 known compounds (1–24), including nine types of structural skeletons. The structures of the compounds were determined by comparison of their physical and spectroscopic data with those reported in literatures. Compounds 13, 22, and 24 were found for the first time within the genus Zanthoxylum, while compound 23 was previously unreported in Z. bungeanum. The chemophenetic significance of isolates was meticulously introduced. Interestingly, compounds 3, 4, and 6 showed significant antimicrobial activity against both normal and drug-resistant strains of Escherichia coli, with their effectiveness comparable to the well-known botanical antibacterial drug berberine. [Display omitted] •A phytochemical investigation of Zanthoxylum bungeanum Maxim. has been carried out.•Twenty-four known compounds were identified from Z. bungeanum.•Four compounds (13, 22, 23, and 24) were first isolated from Z. bungeanum.•Three compounds (3, 4, and 6) showed significant antibacterial activity.•Chemotaxonomic significance of these compounds was discussed.