A dual-responsive supramolecular amphiphile based on cucurbit[7]uril/butyrylcholine host–guest molecular recognition

A host–guest molecular recognition is reported between cucurbit[7]uril and butyrylcholine with the driving forces of hydrophobic and charge-dipole interactions. On the basis of this recognition, an enzyme- and photo-responsive supramolecular amphiphile is fabricated, which self-assembles into vesicl...

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Bibliographic Details
Published inTetrahedron Vol. 72; no. 35; pp. 5290 - 5294
Main Authors Chen, Rener, Gu, Haining, Qiu, Fangli, Zhou, Qizhong, Li, Rongrong, Ye, Yuyuan, Zhuang, Yuguo, Zhang, Jie, Jiang, Huajiang
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.09.2016
Elsevier
Subjects
Butyrylcholine
Chemistry
Chemistry, Organic
Cucurbituril
Dual-responsive
host–guest molecular recognition
Physical Sciences
Science & Technology
Supramolecular amphiphile
Supramolecular amphiphile
host–guest molecular recognition
Butyrylcholine
Dual-responsive
Cucurbituril
VESICLES
RELEASE
OPPORTUNITIES
ALPHA-CYCLODEXTRIN
ASSEMBLIES
host-guest molecular recognition
ORGANIC FRAMEWORK
PROTON-TRANSFER
COMPLEXATION
DERIVATIVES
WATER
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Summary:A host–guest molecular recognition is reported between cucurbit[7]uril and butyrylcholine with the driving forces of hydrophobic and charge-dipole interactions. On the basis of this recognition, an enzyme- and photo-responsive supramolecular amphiphile is fabricated, which self-assembles into vesicles in aqueous solution. The assembly and disassembly of vesicles are successfully employed in stimuli-triggered releases of doxorubicin hydrochloride. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.05.022