Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

• Published in: Chemical science (Cambridge) Vol. 3; no. 1; pp. 177 - 180
• Main Authors: Ackermann, Lutz, Wang, Lianhui, Lygin, Alexander V
• Format: Journal Article
• Language: English
• Published: 01.01.2012
• Subjects: Alkaloids; Alkynes; Analogs; Bonding; Joining; Marine; Pyrroles; Selectivity

Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)2[middle dot]H2O under ambient air. The C-H/N-H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloi...