Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)2[middle dot]H2O under ambient air. The C-H/N-H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloi...

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Bibliographic Details
Published inChemical science (Cambridge) Vol. 3; no. 1; pp. 177 - 180
Main Authors Ackermann, Lutz, Wang, Lianhui, Lygin, Alexander V
Format Journal Article
LanguageEnglish
Published 01.01.2012
Subjects
Alkaloids
Alkynes
Analogs
Bonding
Joining
Marine
Pyrroles
Selectivity
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Summary:Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)2[middle dot]H2O under ambient air. The C-H/N-H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloids.
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ISSN:2041-6520
2041-6539
DOI:10.1039/C1SC00619C