Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs

Hydroxypyridinones (HPs) are a family of N-heterocyclic core chelators which, based on their specific metal-coordination, easy manipulation/derivatization and biocompatibility, have been an attractive target for the development of new pharmaceutical drugs with manifold uses. Herein we describe the m...

Full description

Saved in:
Bibliographic Details
Published inCoordination chemistry reviews Vol. 256; no. 1; pp. 240 - 259
Main Authors Santos, M. Amélia, Marques, Sérgio M., Chaves, Sílvia
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2012
Subjects
3-Hydroxy-4-pyridinones
Anti-neurodegeneratives
Hydroxypyridinones
Iron chelators
Medicinal chemistry
Metallodrugs
Hydroxypyridinones
Iron chelators
Medicinal chemistry
Anti-neurodegeneratives
3-Hydroxy-4-pyridinones
Metallodrugs
Online AccessGet full text

Cover

More Information
Summary:Hydroxypyridinones (HPs) are a family of N-heterocyclic core chelators which, based on their specific metal-coordination, easy manipulation/derivatization and biocompatibility, have been an attractive target for the development of new pharmaceutical drugs with manifold uses. Herein we describe the most recent advances reported in the literature on HPs, with a special focus on the metal chelating properties of the 3-hydroxy-4-pyridinone (3,4-HP) derivatives, and the different approaches used to functionalize these chelators to improve their biological properties, namely in terms of bioavailability and specific bio-targeting abilities. Representative examples of HPs are included, mostly for applications as chelating drugs for sequestration or passivation of metal overload or deregulated biometals, but also as metallodrugs for potential diagnostic/therapeutic purposes. These examples are discussed in terms of the chelating properties and structure–activity relationships.
ISSN:0010-8545
1873-3840
DOI:10.1016/j.ccr.2011.08.008