Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic c...

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Bibliographic Details
Published inRSC advances Vol. 6; no. 112; pp. 111233 - 111238
Main Authors Garg, PanKaj, Pandey, Shambhavi, Kim, Hong-Nam, Seonwoo, Hoon, Park, Sunho, Choi, Kyoung Soon, Jang, Kyoung-Je, Hyun, Hoon, Choung, Phil-Hoon, Kim, Jangho, Chung, Jong Hoon
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Cues
Efficiency
Genes
Mathematical analysis
Nanostructure
Platforms
Strategy
Synergistic effect
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Summary:Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra09348e