Biologic Therapies in Orthopaedic Surgery

In the past several decades, there has been a great interest and demand for biological techniques and approaches to treat an increasing array of musculoskeletal conditions. These “orthobiologic” agents encompass substances that are naturally found in the human body including platelet-rich plasma (PR...

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Bibliographic Details
Published inOperative techniques in orthopaedics Vol. 32; no. 2; p. 100963
Main Authors Su, Charles A., Vopat, Matthew L., Jildeh, Toufic R., Day, Hannah K., Philippon, Marc J., Huard, Johnny
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.06.2022
Subjects
angiogenesis
fibrosis
Freddie Fu
gene therapy
PRP
senescence
stem cells
senescence
stem cells
Freddie Fu
angiogenesis
gene therapy
fibrosis
PRP
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Summary:In the past several decades, there has been a great interest and demand for biological techniques and approaches to treat an increasing array of musculoskeletal conditions. These “orthobiologic” agents encompass substances that are naturally found in the human body including platelet-rich plasma (PRP), isolated growth factors, and gene and cell therapy approaches, and are increasingly used by orthopaedic surgeons and medical providers to theoretically optimize and improve the healing of cartilage, injured muscles, tendons, ligaments, and fractures. Dr Freddie Fu was a pioneer in our field in investigating numerous biologic therapies and their potential therapeutic applications to orthopaedic surgery and improving patient outcomes. This review seeks to highlight Dr Fu's contributions to our understanding of PRP, stem cells, gene therapy, fibrosis, angiogenesis, and senescence.
ISSN:1048-6666
1558-3848
DOI:10.1016/j.oto.2022.100963