The novel synthesis of 5-cyano-1-azabicyclo[3.3.0]octane

5-Cyano-1-azabicyclo[3.3.0]octane (1), which is a key intermediary material to some medicines, was prepared from 1,7-dichloroheptan-4-one (7) via only one step under mild conditions. The reaction mechanism is also discussed.

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Bibliographic Details
Published inHeterocycles Vol. 45; no. 8; pp. 1447 - 1450
Main Authors Oka, M, Matsumoto, Y, Unno, R
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 1997
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PYRROLIZIDINES
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Summary:5-Cyano-1-azabicyclo[3.3.0]octane (1), which is a key intermediary material to some medicines, was prepared from 1,7-dichloroheptan-4-one (7) via only one step under mild conditions. The reaction mechanism is also discussed.
ISSN:0385-5414
DOI:10.3987/com-97-7845