Synthesis and physicochemical mechanistic evaluation of chitosan-based interbiopolyelectrolyte complexes for effective encapsulation of OLZ for potential application in nano-psychiatry

The design and development of more effective biopolymer-based drug delivery and controlled release systems are required to improve pharmaceutical products for psychiatric terapies. In this paper, the synthesis of three types of chitosan-based interbiopolyelectrolyte complexes (IBPECs) with olanzapin...

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Published inSustainable chemistry and pharmacy Vol. 22; p. 100456
Main Authors López-Maldonado, Eduardo Alberto, Oropeza-Guzmán, Mercedes Teresita
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2021
Subjects
Biopolyelectrolytes
Chitosan
Macromolecular complexes
Olanzapine
Zeta potential
Macromolecular complexes
Olanzapine
Chitosan
Zeta potential
Biopolyelectrolytes
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Summary:The design and development of more effective biopolymer-based drug delivery and controlled release systems are required to improve pharmaceutical products for psychiatric terapies. In this paper, the synthesis of three types of chitosan-based interbiopolyelectrolyte complexes (IBPECs) with olanzapine (OLZ) were evaluated. The proposal is an innovative ecofriendly formulations with potential application in nano-psychiatry. IBPECs were strategically synthesized following zeta potential measurements using chitosan (Ch) as the base material and tripropylphosphate (TPP) and alginate (ALG) as cross-linking biopolymers. The effect of TPP and ALG as a crosslinking agent on particle size, surface charge density and colloidal stability in complex formation of TPP/Ch, ALG/Ch and ALG/TPP/Ch were evaluated before and after the incorporation of OLZ at pH = 5.0. The ζ = f (pH) and ζ = f ([TPP/Ch], [ALG/Ch] or [ALG/TPP + Ch]) profiles allowed us to elucidate the supramolecular assembly mechanisms of each formulation and determine the best physicochemical conditions that maximize OLZ encapsulation. [Display omitted] •Chitosan-based interbiopolyelectrolyte complexes (IBPECs) were effective.•New green drug formulations of olanzapine (OLZ) were successfully developed.•Zeta potential measurements allow the synthesis and encapsulation mechanisms in IBPECs.•IBPECs ecofriendly materials that improve the pharmacological function.
ISSN:2352-5541
2352-5541
DOI:10.1016/j.scp.2021.100456