Ionic liquids as modifiers for glass and SU-8 electrochemical microfluidic chips

Ionic liquids have been attracting attention as background additives to improve separations in the last years. This work reports about the use of four ionic liquids (ILs): 1-butyl-4-methylpyridinum tetrafluoroborate (BMPyBF4), 1-butyl-3-methylimidazolium tetrafluoroborate (BMIMBF4), 1-butyl-3-methyl...

Full description

Saved in:
Bibliographic Details
Published inSensors and actuators. B, Chemical Vol. 188; pp. 837 - 846
Main Authors Álvarez-Martos, Isabel, García Alonso, Francisco Javier, Anillo, Adela, Arias-Abrodo, Pilar, Gutiérrez-Álvarez, María Dolores, Costa-García, Agustín, Fernández-Abedul, María Teresa
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2013
Subjects
Catecholamines
End-channel amperometric detection
Glass microchips
Ionic liquids
Microchip electrophoresis
SU-8 microchips
Ionic liquids
Catecholamines
Glass microchips
Microchip electrophoresis
End-channel amperometric detection
SU-8 microchips
Online AccessGet full text

Cover

More Information
Summary:Ionic liquids have been attracting attention as background additives to improve separations in the last years. This work reports about the use of four ionic liquids (ILs): 1-butyl-4-methylpyridinum tetrafluoroborate (BMPyBF4), 1-butyl-3-methylimidazolium tetrafluoroborate (BMIMBF4), 1-butyl-3-methylimidazolium hydrogen sulfate (BMIMHSO4) and 1-ethyl-3-methylimidazolium methyl sulfate (EMIMMeSO4) as dynamic modifiers in glass and SU-8 microchip electrophoresis (ME). The influence of varying pH values and ILs concentration on the detection system was investigated. Moreover, ionic liquids with different cations and counterions were evaluated as background additives choosing two catecholamines (dopamine, DA and epinephrine, E) as model analytes. Dynamic modification with ILs proved to be necessary to obtain enhanced mixture separation in both 30mm glass and SU-8 MEs. Good precision in terms of migration times and resolution was obtained for both kinds of MEs when ILs were employed. In addition, baseline resolution with good reproducibility over time (RSD values of 0.5% and 0.8% for migration times in one experiment and three days, respectively) was achieved in glass MEs with 60mm effective separation length.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2013.07.068