Multicomponent assembling of imidazole N-oxides, aldehydes and CH-acids: A simple and efficient approach to newly functionalized imidazole derivatives

An efficient and simple method for C2-functionalization of 2-unsubstituted imidazole N-oxides has been developed. It consists at the condensation of 2-unsubstituted imidazole N-oxides with aldehydes and CH-acids. This method permits broad variations in the structure of starting materials. [Display o...

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Bibliographic Details
Published inTetrahedron Vol. 73; no. 47; pp. 6669 - 6675
Main Authors Mityanov, Vitaly S., Kutasevich, Anton V., Krayushkin, Michail M., Lichitsky, Boris V., Dudinov, Arkady A., Komogortsev, Andrey N., Koldaeva, Tatyana Yu, Perevalov, Valery P.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 23.11.2017
Elsevier
Subjects
CH-acids
CH-functionalization
Chemistry
Chemistry, Organic
Imidazole N-oxides
Multicomponent reaction
Physical Sciences
Science & Technology
CH-acids
Multicomponent reaction
Imidazole N-oxides
CH-functionalization
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Summary:An efficient and simple method for C2-functionalization of 2-unsubstituted imidazole N-oxides has been developed. It consists at the condensation of 2-unsubstituted imidazole N-oxides with aldehydes and CH-acids. This method permits broad variations in the structure of starting materials. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2017.10.026