Evaluation of a Novel MAGEC1 Variant and Susceptibility to Ovarian Cancer in the North Indian Population

• Published in: Genetic testing and molecular biomarkers Vol. 29; no. 7; p. 179
• Main Authors: Sharma, Minerva, Verma, Sonali, Bhagat, Vanshika, Tufail, Ziya, Jamwal, Rajeshwer Singh, Sharma, Bhawani, Chander, Gresh, Shah, Ruchi, Bhat, Audesh, Dhar, Manushi, Singh, Supinder, Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: United States 01.07.2025
• Subjects: Adult; Aged; Alleles; Antigens, Neoplasm - genetics; Antigens, Neoplasm - metabolism; Case-Control Studies; Female; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genotype; Humans; India; Middle Aged; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Odds Ratio; Ovarian Neoplasms - genetics; Polymorphism, Single Nucleotide - genetics; India; MAGEC1; Jammu and Kashmir; Sanger sequencing
• ISSN: 1945-0257
• DOI: 10.1089/gtmb.2025.0029

To check the correlation between the MAGE Family Member C1 ( gene variant rs176036 and ovarian cancer risk among the Jammu and Kashmir population. A case-control association study of the gene variant rs176036 (G > A) and ovarian cancer. The variation was identified through whole exome sequencing, and the selected variant was genotyped in 111 patients with ovarian cancer and 107 healthy controls belonging to the Jammu and Kashmir region of North India using Sanger sequencing to confirm its association with the ovarian cancer. Odds ratio (OR) and other statistical values were calculated using standard tools. The allelic frequency distribution was found to be similar between cases and controls, with the dominant allele (G) present in 89.6% of cases and 90.2% of controls ( = 0.84). The allelic OR for the dominant allele was 1.08 (0.55-2.11), which is nonsignificant ( = 0.83). The present study suggests that the rs176036 variant does not confer any increased risk of ovarian cancer among population of Jammu and Kashmir.