Biomedical applications of Pt(II) metallacycle/metallacage-based agents: From mono-chemotherapy to versatile imaging contrasts and theranostic platforms

•The importance of molecular imaging-guided Pt(II) metallacycles/metallacages chemotherapy, which can precisely provide powerful tools for monitoring and evaluating their biodistribution and therapy efficiency.•The importance of the combination of Pt(II) metallacycles/metallacages with phototherapy....

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Bibliographic Details
Published inCoordination chemistry reviews Vol. 443; p. 214017
Main Authors Tuo, Wei, Xu, Yuling, Fan, Yifan, Li, Jun, Qiu, Mingqiang, Xiong, Xiaoxing, Li, Xiangyang, Sun, Yao
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.09.2021
Subjects
Biomedical applications
Chemotherapy
Imaging contrasts
Pt(II) metallacycle/metallacage
Theranostic
Pt(II) metallacycle/metallacage
Chemotherapy
Biomedical applications
Imaging contrasts
Theranostic
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Summary:•The importance of molecular imaging-guided Pt(II) metallacycles/metallacages chemotherapy, which can precisely provide powerful tools for monitoring and evaluating their biodistribution and therapy efficiency.•The importance of the combination of Pt(II) metallacycles/metallacages with phototherapy. The synergistic chemo-phototherapy demonstrated advantages to address the issues of chemotherapy.•The combination of chemo-phototherapy and imaging platform can be readily built from the Pt(II) metallacycles/metallacages, which could show huge potentials in molecular imaging, materials science, and biomedicine. Platinum-based coordination chemistry has laid the foundation for the development of numerous metal complexes and provoked their applications in cancer chemotherapy. It is noteworthy that Pt(II) metallacyles/metallacages formed through coordination-driven self-assembly exhibit improved optical properties and superior anticancer efficacies in comparison with their precursors. To this end, the employment of metallacycles/metallacages as chemotherapy agents, imaging contrasts and multifunctional theranostic platforms has attracted tremendous attention. In this context, we provide an insight into the progression of Pt(II) metallacycles/metallacages from mono-chemotherapeutic agents to versatile imaging contrasts and theranostic platforms.
ISSN:0010-8545
1873-3840
DOI:10.1016/j.ccr.2021.214017