Schistosoma mansoni modulation of phagocytosis in Biomphalaria glabrata

Both short-term (3 hr) exposure of Biomphalaria glabrata snails (M-line and 13-16-R1) to Schistosoma mansoni (PR1) miracidia and in vitro incubation of parasite sporocysts with host hemolymph components altered host phagocytic ability. Hemocytes obtained from susceptible (M-line) snails that had bee...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of parasitology Vol. 76; no. 1; p. 45
Main Authors Fryer, S E, Bayne, C J
Format Journal Article
LanguageEnglish
Published United States 01.02.1990
Subjects
Animals
Biomphalaria - immunology
Biomphalaria - parasitology
Blood Cell Count
Blood Cells - immunology
Hemocytes - immunology
Hemolymph - immunology
Hemolymph - parasitology
Host-Parasite Interactions
Opsonin Proteins
Phagocytosis
Schistosoma mansoni - immunology
Yeasts - immunology
Online AccessGet more information

Cover

More Information
Summary:Both short-term (3 hr) exposure of Biomphalaria glabrata snails (M-line and 13-16-R1) to Schistosoma mansoni (PR1) miracidia and in vitro incubation of parasite sporocysts with host hemolymph components altered host phagocytic ability. Hemocytes obtained from susceptible (M-line) snails that had been exposed to parasite miracidia for 3 hr showed reduced levels of phagocytosis of yeast cells in vitro compared to hemocytes from unexposed individuals. Incubation of whole hemolymph with sporocysts in vitro also reduced yeast phagocytosis in this susceptible strain. In contrast, resistant (13-16-R1) hemocytes showed increased levels of yeast phagocytosis after in vitro incubation with the parasite, and the opsonic properties of 13-16-R1 plasma were greater after exposure of snails to miracidia. These strain-specific effects of S. mansoni on host hemocyte phagocytosis and plasma opsonization were seen only when both plasma and hemocytes were present at the time of exposure to the parasite.
ISSN:0022-3395
DOI:10.2307/3282626