Silylated β-enaminones as precursors in the regioselective synthesis of silyl pyrazoles

Silyl β-enaminones have been synthesized by reductive cleavage of 5-silyl, 3-, 4- and 5-silylmethylisoxazoles.These versatile synthons bearing different silyl groups in various positions of the enaminoketonic system are of great interest in the regioselective synthesis of 3- or 5-silylpyrazoles and...

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Published inTetrahedron Vol. 62; no. 4; pp. 611 - 618
Main Authors Calle, Mariola, Calvo, Luis A., González-Ortega, Alfonso, González-Nogal, Ana M.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 23.01.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Silicon isoxazoles
Silicon pyrazoles
Silicon β-enaminones
Silicon isoxazoles
Silicon β-enaminones
Silicon pyrazoles
silicon isoxazoles
silicon beta-enaminones
silicon pyrazoles
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Summary:Silyl β-enaminones have been synthesized by reductive cleavage of 5-silyl, 3-, 4- and 5-silylmethylisoxazoles.These versatile synthons bearing different silyl groups in various positions of the enaminoketonic system are of great interest in the regioselective synthesis of 3- or 5-silylpyrazoles and 3-, 4- or 5-silylmethylpyrazoles, which can serve as building blocks in heterocyclic chemistry. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2005.10.001