Optimisation and scale-up of microwave assisted cyanation

A microwave enhanced palladium catalysed cyanation procedure was optimised for the final step of a production method for citalopram 2 . The method was demonstrated on multigram batch scale for the synthesis of escitalopram ( S)- 2 and then in a stop-flow continuous process for citalopram. A microwav...

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Bibliographic Details
Published inTetrahedron Vol. 62; no. 19; pp. 4705 - 4708
Main Authors Pitts, Michael R., McCormack, Peter, Whittall, John
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 08.05.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Citalopram
Cyanation
Microwave assisted chemistry
Palladium catalysis
Physical Sciences
Science & Technology
Microwave assisted chemistry
Cyanation
Palladium catalysis
Citalopram
palladium catalysis
ORGANIC-SYNTHESIS
CONVENIENT
CONJUNCTION
ARYL BROMIDES
cyanation
COUPLING REACTIONS
AROMATIC HALIDES
NITRILES
CHLORIDES
microwave assisted chemistry
PALLADIUM-CATALYZED CYANATION
citalopram
CYANIDE
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Summary:A microwave enhanced palladium catalysed cyanation procedure was optimised for the final step of a production method for citalopram 2 . The method was demonstrated on multigram batch scale for the synthesis of escitalopram ( S)- 2 and then in a stop-flow continuous process for citalopram. A microwave enhanced palladium catalysed cyanation procedure was optimised for citalopram. The method was demonstrated on multigram batch scale for the synthesis of escitalopram and in a stop-flow continuous process for citalopram. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2005.11.095