Secondary metabolites produced by mangrove endophytic fungus Aspergillus fumigatus HQD24 with immunosuppressive activity

• Published in: Biochemical systematics and ecology Vol. 93; p. 104166
• Main Authors: Xu, Zhi-Yong, Zhang, Xue-Xia, Ma, Jian-Kun, Yang, Yong, Zhou, Jing, Xu, Jing
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2020
• Subjects: Alkaloids; Aspergillus fumigatus HQD24; Immunosuppressive activity; Mangrove endophytic fungi; Polyketides; Alkaloids; Polyketides; Immunosuppressive activity; Mangrove endophytic fungi; Aspergillus fumigatus HQD24
• ISSN: 0305-1978; 1873-2925
• DOI: 10.1016/j.bse.2020.104166

Immunosuppressive activity guided chemical investigation, four alkaloids (1–4) and eight polyketides (5–12) were isolated from mangrove-derived Aspergillus fumigatus HQD24. Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. Compounds 1 and 3–5 were separated from mangrove endophytic fungi for the first time, 3 and 12 were firstly recovered from fungal genus Aspergillus. Compound 5 remarkable inhibited proliferation of ConA (concanavalin A)-induced T and LPS (lipopolysaccharide)-induced B murine spleen lymphocytes, with IC50 of 12.11 ± 0.11 μM and 62.66 ± 0.80 μM, respectively. Meanwhile, the chemotaxonomic relations of isolated compounds and Aspergillus species were also discussed. •Four alkaloids and eight polyketides were isolated from mangrove-derived Aspergillus fumigatus HQD24.•Compound 5 exhibited remarkable immunosuppressive activity.•The chemotaxonomic relations of A. fumigatus and other species of Aspergillus were disclosed.