Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release

• Published in: Coordination chemistry reviews Vol. 364; pp. 51 - 85
• Main Authors: Gu, Haibin, Mu, Shengdong, Qiu, Guirong, Liu, Xiong, Zhang, Li, Yuan, Yanfei, Astruc, Didier
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2018
• Subjects: Controlled release; Drug delivery; Ferrocene; Metallopolymer; Nanomedicine; Stimuli-responsiveness; Supramolecular polymers; PEI-6-CD; LUVs; PFcMA; PVFc-b-P2VP; E-QCM; RITC-dextran; IC50; SMMC-7; DMPA; RAFT; PFS; HCPT; PEG-diFc; PISA; SDS; mPEG-β-CD; PEI-Fc; Fc-SS-β-CD; Py; βCDPSH; DOX; GEM; AAO; MSNs; Fc-PCL; FACP5; Fc-HEUR; Dextran-Alexa 488; DPDS; LCST; Stimuli-responsiveness; MMP-9; mPEG-Fc; Fc-PS-PTMSPMA; Fc-β-CD; Ad; PS-CD NPs; DOX·HCl; MCF-7; Fc-DSP; PS-β-CD; Nanomedicine; LCMs; MSE; Controlled release; CB; NCs; Fc-CHO; HMSs; CD-PCL; Fc-POEGMA; GUVs; EDTA; Fc-CPT; HP-β-CD; Ferrocene; PAA; LbL; WP6; TCEP; β-CD2; 5-FU; M-DDSs; P(NIPAM-co-AMA)-b-PMMA; ITO; CPT; A549; MRP1 siRNA; FCAP; DS; PNIPAM-P; MTZ; MAEFc; mPEG-Ada; MG; PEI-2-CD; CLSM; MCs; MNPs; PAEFC-b-PDMAEMA; R6G; CAC; PNIPAM-β-CD; MEA; PAH or PAH; RhB; Supramolecular polymers; ATRP; PVFc-b-PMMA-b-PDMAEMA; PSS; pDNA; β-CD-hydrazone-DOX; LCVs; ROS; DDA; PVFcium; TTC; NR; DTT; 6-Ts-β-CD; PVFc-b-PMMA; PAH-Fc; Drug delivery; PMDETA; FCAPa; Fcium; PVFc-b-PEG; SKOV-3; DDS; PTX; AuNPs; HepG2; PEG-b-PMAEFc; Fc; GSH; ALMA; CSP; DSPC; DSPE; PEO-Fc; DSPG; Dextran-TRITC; MSNPs; PEG-Fc; PACMO-b-PAEFC; NPs; PA; β-CD; PC; Fc2; TEG; PDMAEMA-b-PBzMA-b-PVFC; FcPEG; Metallopolymer
• ISSN: 0010-8545; 1873-3840
• DOI: 10.1016/j.ccr.2018.03.013

[Display omitted] •Supramolecular drug delivery use ferrocenyl-containing polymers.•Controlled drug release involve the redox stimuli of ferrocenyl groups in polymers.•Ferrocene combined with β-cyclodextrin or pillar[6]arene provide drug delivery system.•Supramolecular and therapeutic aspects of polymeric redox ferrocenes in nanomedicine.•The redox stimuli of supramolecular ferrocene polymers is used for drug delivery. The chemically and electrochemically reversible ferrocene/ferricinium redox couple has attracted considerable attention, and a major application is dynamic redox switching of drug delivery systems (DDSs) constructed with ferrocenyl (Fc)-containing polymers. Owing to the accompanying hydrophobic/hydrophilic, neutral/cationic and complexation/dissociation transitions, the “on-demand” release of loaded drugs has been achieved in response to external redox stimuli. Thus, Fc-containing polymers provide a flexible and robust platform for the design and development of functional and smart DDSs. This review summarizes the most recent progress in the fabrication of DDSs with Fc-containing polymers based on the host–guest interactions of Fc/β-cyclodextrin (β-CD) and pillar[6]arene (PA). Fabrication techniques include solution self-assembly, mini-emulsion, layer-by-layer and template techniques. These Fc-containing polymers involve main-chain, side-chain and dendritic topologies in which the polymers behave in various supramolecular fashions. The discussed DDSs contain micelles, vesicles, nanoparticles, nanotubes, multilayer films and bulk hydrogels, and the corresponding stimuli involves electrochemistry, redox reagents, pH and temperature. Focus also is on the mechanisms of stimuli-responsiveness, fabrication methods, controlled release behaviors and potential applications of these DDSs including synergy with medicinal properties of ferrocene derivatives. The prospects of Fc-containing polymer-based DDSs are in nanomedicine whereby it will be possible to selectively deliver specific drugs to sick organs. Many studies detailed here concern chemical studies that still need to be adapted to in vitro, then in vivo studies in animals. From that point an ultimate and formidable challenge will consist in adapting such DDSs to man diagnosis and therapy.