Synthesis, Characterisation and Crystal structure of a New Cu(II)-carboxamide Complex and CuO nanoparticles as New Catalysts in the CuAAC reaction and Investigation of their Antibacterial activity

• Published in: Inorganica Chimica Acta Vol. 506; p. 119514
• Main Authors: Kiani, Mahsa, Bagherzadeh, Mojtaba, Meghdadi, Soraia, Fadaei-Tirani, Farzaneh, Babaie, Maryam, Schenk-Joß, Kurt
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2020
• Subjects: Azide–alkyne cycloaddition and antibacterial activity; Copper oxide; Cu(II)-carboxamide complex; N-(thiazole-2-yl) picolinamide; Azide–alkyne cycloaddition and antibacterial activity; Cu(II)-carboxamide complex; Copper oxide; N-(thiazole-2-yl) picolinamide
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2020.119514

[Display omitted] •The Cu(II)-carboxamide complex was prepared with N-(thiazole-2-yl) picolinamide.•CuO nanoparticles has been prepared by thermal decomposition using Cu(II) complex.•Crystal structure of Cu(II) complex was discussed.•The catalytic activity of Cu(II) complex and CuO was investigated in water under mild conditions.•The antibacterial activity was investigated for Cu(II) complex and CuO. The bidentate carboxamide ligand N-(thiazole-2-yl) picolinamide (LH) was synthesized in the environmentally friendly ionic liquid TBAB, and the five-coordinated CuII-complex, [Cu(L)2(H2O)].CHCl3(1) was synthesized from LH and copper(II)acetate. Cupric oxide [CuO] nanoparticles (2) have been prepared by the thermal decomposition of (1) as a new precursor at 600 °C for 3 h under air atmosphere. (1) was characterised using FT-IR spectroscopy, elemental analyses and its solid state structure was confirmed by single crystal X-ray diffraction. (2) were identified by FT-IR spectroscopy, X-ray powder diffraction, scanning electron microscopy, energy dispersive X-ray analysis and thermo-gravimetric differential thermal analyses. The electrochemical behaviour of LH and (1) has been investigated by cyclic voltammetry: irreversible CuII/I reductions were observed. The catalytic activity of (1) and (2) were evaluated in the one-pot azide–alkyne cycloaddition click reaction in water without additional agents. LH, (1) and (2) were also screened for their in vitro antibacterial activity: they showed promising antibacterial activity comparable to that of the antibiotic penicillin.