Lactones: Classification, synthesis, biological activities, and industrial applications

This review summarizes the current knowledge on lactones, a class of biologically active natural products isolated from a wide range of living organisms. Butenolide, 5,6-dihydropyran-2-one, and sesquiterpene lactones display an impressive variety of bioactivities and are the most abundant in nature....

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Published inTetrahedron Vol. 84; p. 132001
Main Authors Sartori, Suélen Karine, Diaz, Marisa Alves Nogueira, Diaz-Muñoz, Gaspar
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 26.03.2021
Subjects
5,6-Dihydropyran-2-one
Bioactivity
Butenolide
Lactone family
Macrolactone
Bioactivity
Lactone family
5,6-Dihydropyran-2-one
Butenolide
Macrolactone
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Abstract This review summarizes the current knowledge on lactones, a class of biologically active natural products isolated from a wide range of living organisms. Butenolide, 5,6-dihydropyran-2-one, and sesquiterpene lactones display an impressive variety of bioactivities and are the most abundant in nature. This paper provides a compilation of ring construction strategies for the synthesis of small, medium, and macrolactones and discusses their biological activities and industrial, pharmaceutical, and agrochemical applications. [Display omitted] •This review summarizes the current knowledge on lactones.•Lactones display an impressive variety of bioactivities.•Simple, medium lactonic rings to macrolactones were stereoselectively synthesized.•Lactone family have received considerable attention from the scientific community.
AbstractList This review summarizes the current knowledge on lactones, a class of biologically active natural products isolated from a wide range of living organisms. Butenolide, 5,6-dihydropyran-2-one, and sesquiterpene lactones display an impressive variety of bioactivities and are the most abundant in nature. This paper provides a compilation of ring construction strategies for the synthesis of small, medium, and macrolactones and discusses their biological activities and industrial, pharmaceutical, and agrochemical applications. [Display omitted] •This review summarizes the current knowledge on lactones.•Lactones display an impressive variety of bioactivities.•Simple, medium lactonic rings to macrolactones were stereoselectively synthesized.•Lactone family have received considerable attention from the scientific community.
ArticleNumber 132001
Author Diaz-Muñoz, Gaspar
Sartori, Suélen Karine
Diaz, Marisa Alves Nogueira
Author_xml – sequence: 1
  givenname: Suélen Karine
  surname: Sartori
  fullname: Sartori, Suélen Karine
  organization: Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil
– sequence: 2
  givenname: Marisa Alves Nogueira
  surname: Diaz
  fullname: Diaz, Marisa Alves Nogueira
  organization: Department of Biochemistry and Molecular Biology, Federal University of Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil
– sequence: 3
  givenname: Gaspar
  surname: Diaz-Muñoz
  fullname: Diaz-Muñoz, Gaspar
  email: gaspardm@qui.ufmg.br
  organization: Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil
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Keywords Bioactivity
Lactone family
5,6-Dihydropyran-2-one
Butenolide
Macrolactone
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Snippet This review summarizes the current knowledge on lactones, a class of biologically active natural products isolated from a wide range of living organisms....
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SubjectTerms 5,6-Dihydropyran-2-one
Bioactivity
Butenolide
Lactone family
Macrolactone
Title Lactones: Classification, synthesis, biological activities, and industrial applications
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