Lactones: Classification, synthesis, biological activities, and industrial applications

This review summarizes the current knowledge on lactones, a class of biologically active natural products isolated from a wide range of living organisms. Butenolide, 5,6-dihydropyran-2-one, and sesquiterpene lactones display an impressive variety of bioactivities and are the most abundant in nature....

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Bibliographic Details
Published inTetrahedron Vol. 84; p. 132001
Main Authors Sartori, Suélen Karine, Diaz, Marisa Alves Nogueira, Diaz-Muñoz, Gaspar
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 26.03.2021
Subjects
5,6-Dihydropyran-2-one
Bioactivity
Butenolide
Lactone family
Macrolactone
Bioactivity
Lactone family
5,6-Dihydropyran-2-one
Butenolide
Macrolactone
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Summary:This review summarizes the current knowledge on lactones, a class of biologically active natural products isolated from a wide range of living organisms. Butenolide, 5,6-dihydropyran-2-one, and sesquiterpene lactones display an impressive variety of bioactivities and are the most abundant in nature. This paper provides a compilation of ring construction strategies for the synthesis of small, medium, and macrolactones and discusses their biological activities and industrial, pharmaceutical, and agrochemical applications. [Display omitted] •This review summarizes the current knowledge on lactones.•Lactones display an impressive variety of bioactivities.•Simple, medium lactonic rings to macrolactones were stereoselectively synthesized.•Lactone family have received considerable attention from the scientific community.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2021.132001