An Efficient Method for the Synthesis of N‐uracil‐4‐oxo‐thiazolidines without Catalyst

We have developed highly efficient, one‐pot three component reaction of 5‐amino‐uracil and aromatic aldehydes with thioglycolic acid for the synthesis of N‐uracil‐thiazolidinones in excellent yields. The same products were also prepared by the reaction of Schiff bases of 5‐amino‐uracil with thioglyc...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 56; no. 8; pp. 2099 - 2104
Main Authors Mohamed, Asmaa H., Shaker, Raafat M.
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.08.2019
Wiley Subscription Services, Inc
Subjects
Aldehydes
Catalysts
Chemistry
Chemistry, Organic
Imines
Physical Sciences
Science & Technology
Uracil
HETEROCYCLIC SYNTHESIS
IN-VITRO
EXPEDITIOUS SYNTHESIS
5-AMINOURACIL
ONE-POT SYNTHESIS
BIOLOGICAL-ACTIVITY
URACIL DERIVATIVES
IONIC LIQUID
MICROWAVE IRRADIATION
BUILDING-BLOCK
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Summary:We have developed highly efficient, one‐pot three component reaction of 5‐amino‐uracil and aromatic aldehydes with thioglycolic acid for the synthesis of N‐uracil‐thiazolidinones in excellent yields. The same products were also prepared by the reaction of Schiff bases of 5‐amino‐uracil with thioglycolic acid. In addition, benzylation of thiazolidinone derivatives and Schiff bases by using benzyl chloride was investigated. The results obtained from elemental microanalysis and different spectral data are in agreement with the assigned structures.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3589