Identification, isolation, and characterization of two novel impurities from phenothiazine heterocycle derivative: Perphenazine and their control in the process

• Published in: Journal of heterocyclic chemistry Vol. 59; no. 6; pp. 1054 - 1063
• Main Authors: Chaudhari, Ashok, Pramanik, Chinmoy, Patil, Pradeep, Vedpathak, Hanmant, Bandishti, Mahesh, Tripathy, Narendra K., Gurjar, Mukund K.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Inc 01.06.2022; Wiley; Wiley Subscription Services, Inc
• Subjects: Chemistry; Chemistry, Organic; High performance liquid chromatography; Impurities; Perphenazine; Physical Sciences; Science & Technology; CHEMILUMINESCENCE METHOD; ACID

During the process development of perphenazine, two unknown impurities were found by high‐performance liquid chromatography (HPLC) analysis. These two impurities were further identified, isolated, and characterized form the mother liquor. These two impurities were found novel in the process of perph...