Identification, isolation, and characterization of two novel impurities from phenothiazine heterocycle derivative: Perphenazine and their control in the process

During the process development of perphenazine, two unknown impurities were found by high‐performance liquid chromatography (HPLC) analysis. These two impurities were further identified, isolated, and characterized form the mother liquor. These two impurities were found novel in the process of perph...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 59; no. 6; pp. 1054 - 1063
Main Authors Chaudhari, Ashok, Pramanik, Chinmoy, Patil, Pradeep, Vedpathak, Hanmant, Bandishti, Mahesh, Tripathy, Narendra K., Gurjar, Mukund K.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Inc 01.06.2022
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Organic
High performance liquid chromatography
Impurities
Perphenazine
Physical Sciences
Science & Technology
CHEMILUMINESCENCE METHOD
ACID
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Summary:During the process development of perphenazine, two unknown impurities were found by high‐performance liquid chromatography (HPLC) analysis. These two impurities were further identified, isolated, and characterized form the mother liquor. These two impurities were found novel in the process of perphenazine. Also the reaction conditions were controlled for commercial manufacturing of perphenazine with overall good yield and minimal side reactions with control of these two novel impurities. Developed the efficient and cost‐effective process for the manufacturing of antiemetic drug perphenazine with high purity by removing these two impurities from perphenazine and successfully utilized the process for commercial production of perphenazine in our organization.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4445