Drug Reaction To Ursodeoxycholic Acid: Lichenoid Drug Eruption In An Infant Using Ursodeoxycholic Acid For Neonatal Hepatitis

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 35; no. 3; pp. 384 - 386
• Main Authors: Büyükgebiz, Benal, Arslan, Nur, Oztürk, Yeşim, Soyal, Cüneyt, Lebe, Banu
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01.09.2002; Lippincott
• Subjects: Biological and medical sciences; Cholagogues and Choleretics - adverse effects; Drug toxicity and drugs side effects treatment; Hepatitis - drug therapy; Humans; Infant; Lichenoid eruptions; Lichenoid Eruptions - etiology; Male; Medical sciences; Pharmacology. Drug treatments; Toxicity: skin, dermoskeleton; Ursodeoxycholic acid; Ursodeoxycholic Acid - adverse effects; Human; Skin disease; Neonatal; Hepatic disease; Cytotoxicity; Infant; Ursodeoxycholic acid; Case study; Hepatitis; Treatment; Lichenoid dermatosis; Digestive diseases; Skin
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1002/j.1536-4801.2002.tb07842.x

ABSTRACT Lichenoid drug eruptions are skin reactions associated with a number of drugs and chemicals. They are rare in infants. We report here an infant who presented with neonatal hepatitis and who was being treated with ursodeoxycholic acid. The infant developed lichenoid skin eruptions in the third week of the therapy. The lesions have resolved two months after the discontinuation of the drug. To our knowledge, this is the first infant case of lichenoid drug eruption associated with ursodeoxycholic acid.