Newly Formed Bone in Mandible Decortication Experimental Model Using rhBMP-2 Evaluated by Densitometric Study

The purpose of this study was to evaluate the newly formed bone, comparing two different carriers for rhBMP-2, using the decortication and nondecorticatication surgical technique in Wistar rat mandibles, evaluated by radiographic densitometry method. It was used fifty six animals according to specif...

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Published inInternational journal of morphology Vol. 26; no. 1; pp. 83 - 88
Main Authors Issa, João Paulo Mardegan, Tiossi, Rodrigo, Watanabe, Plauto Christopher Aranha, Siéssere, Selma, Regalo, Simone Cecílio Hallak, Lopes, Ruberval Armando, Di Matteo, Miguel Angel Sala, Iyomasa, Mamie Mizusaki, Defino, Helton Luiz Aparecido
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedad Chilena de Anatomía 01.03.2008
Subjects
ANATOMY & MORPHOLOGY
Radiography
rhBMP-2
Mandible
Densitometry
Bone
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Summary:The purpose of this study was to evaluate the newly formed bone, comparing two different carriers for rhBMP-2, using the decortication and nondecorticatication surgical technique in Wistar rat mandibles, evaluated by radiographic densitometry method. It was used fifty six animals according to specific treatment, which were sacrificed after 3 and 6 weeks after this. It was concluded that the decortication surgical technique was able to optimize the osteoinduction properties of the rhBMP-2, independently of the material carrier used and the period of time, according to radiographic densitometry technique.
ISSN:0717-9502
0717-9502
DOI:10.4067/S0717-95022008000100014