Synthesis of Dibenzo [a, d] cycloheptenylacetic Acids

10, 11-Dihydro-10-oxo-5H-dibenzo [a, d] cycloheptenylacetic acids (2a-c) and 11-oxo analogs (2d-f) were prepared from the corresponding diphenylmethanediacetic acids by cyclization. 2-(10, 11-Dihydro-11-oxo-5H-dibenzo [a, d] cyclohepten-2-yl) propionic acid was also prepared from its acetic acid der...

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Published inYAKUGAKU ZASSHI Vol. 101; no. 7; pp. 614 - 628
Main Authors TANAKA, TERUO, SAITO, KUNIRO, NARITA, SENICHI, GOTO, TAKAO, YAMADA, SHINICHI
Format Journal Article
LanguageJapanese
English
Published The Pharmaceutical Society of Japan 01.01.1981
Subjects
10, 11-dihydro-10-oxo-5H-dibenzo [a, d]-cycloheptene
3-isochromanone
5H-dibenzo [a, d] cycloheptene
acetic acid derivatives
antiinflammatory
cyclization
ulcerogenic
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Summary:10, 11-Dihydro-10-oxo-5H-dibenzo [a, d] cycloheptenylacetic acids (2a-c) and 11-oxo analogs (2d-f) were prepared from the corresponding diphenylmethanediacetic acids by cyclization. 2-(10, 11-Dihydro-11-oxo-5H-dibenzo [a, d] cyclohepten-2-yl) propionic acid was also prepared from its acetic acid derivative (2e) in four steps. Their antiinflammatory and ulcerogenic effects were examined. Some of them showed potent antiinflammatory activity in carrageenin rat paw edema and weaker effect than indomethacin in causing gastrointestinal lesions.
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.101.7_614