Growth Factors in Fibrotic Diseases

IN this issue Martinet et al. 1 report that alveolar macrophages from patients with idiopathic pulmonary fibrosis release a growth-promoting activity similar to platelet-derived growth factor (PDGF), and show that the amount of this activity is four times greater than that of the PDGF-like activity...

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Published inThe New England journal of medicine Vol. 317; no. 4; pp. 236 - 237
Main Authors Deuel, Thomas F, Senior, Robert M
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.07.1987
Subjects
Cell growth
Fibroblasts
Genes
Growth factors
Growth Substances - physiology
Humans
Macrophages - secretion
Neutrophils
Platelet-Derived Growth Factor - secretion
Polypeptides
Proteins
Pulmonary Alveoli - secretion
Pulmonary fibrosis
Pulmonary Fibrosis - metabolism
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Abstract IN this issue Martinet et al. 1 report that alveolar macrophages from patients with idiopathic pulmonary fibrosis release a growth-promoting activity similar to platelet-derived growth factor (PDGF), and show that the amount of this activity is four times greater than that of the PDGF-like activity released from alveolar macrophages from normal subjects. Assays of chemotaxis and growth-promoting activity established that the mitogen secreted from macrophages was active, and the identity of the secreted activity was suggested by receptor-competition assays and by blockade of its biologic activity with anti-PDGF serum. The results are important, correlating an increased level of a secreted growth . . .
AbstractList [...]PDGF is chemotactic for neutrophils and monocytes,14 and it induces superoxide anion formation, cell adhesion, cell aggregation, and lysosomal granule release from neutrophils and monocytes.15,16 The chemotactic activity and activation of inflammatory cells occur at PDGF concentrations below those found in human serum17 and thus at concentrations likely to be found within wounds.
IN this issue Martinet et al. 1 report that alveolar macrophages from patients with idiopathic pulmonary fibrosis release a growth-promoting activity similar to platelet-derived growth factor (PDGF), and show that the amount of this activity is four times greater than that of the PDGF-like activity released from alveolar macrophages from normal subjects. Assays of chemotaxis and growth-promoting activity established that the mitogen secreted from macrophages was active, and the identity of the secreted activity was suggested by receptor-competition assays and by blockade of its biologic activity with anti-PDGF serum. The results are important, correlating an increased level of a secreted growth . . .
Author Deuel, Thomas F
Senior, Robert M
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CitedBy_id crossref_primary_10_1016_0360_3016_94_00477_3
crossref_primary_10_1111_j_1600_0560_2009_01313_x
crossref_primary_10_1007_BF03346881
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Snippet IN this issue Martinet et al. 1 report that alveolar macrophages from patients with idiopathic pulmonary fibrosis release a growth-promoting activity similar...
[...]PDGF is chemotactic for neutrophils and monocytes,14 and it induces superoxide anion formation, cell adhesion, cell aggregation, and lysosomal granule...
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StartPage 236
SubjectTerms Cell growth
Fibroblasts
Genes
Growth factors
Growth Substances - physiology
Humans
Macrophages - secretion
Neutrophils
Platelet-Derived Growth Factor - secretion
Polypeptides
Proteins
Pulmonary Alveoli - secretion
Pulmonary fibrosis
Pulmonary Fibrosis - metabolism
Title Growth Factors in Fibrotic Diseases
URI http://dx.doi.org/10.1056/NEJM198707233170409
https://www.ncbi.nlm.nih.gov/pubmed/3600714
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Volume 317
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