Growth Factors in Fibrotic Diseases

IN this issue Martinet et al. 1 report that alveolar macrophages from patients with idiopathic pulmonary fibrosis release a growth-promoting activity similar to platelet-derived growth factor (PDGF), and show that the amount of this activity is four times greater than that of the PDGF-like activity...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 317; no. 4; pp. 236 - 237
Main Authors Deuel, Thomas F, Senior, Robert M
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.07.1987
Subjects
Cell growth
Fibroblasts
Genes
Growth factors
Growth Substances - physiology
Humans
Macrophages - secretion
Neutrophils
Platelet-Derived Growth Factor - secretion
Polypeptides
Proteins
Pulmonary Alveoli - secretion
Pulmonary fibrosis
Pulmonary Fibrosis - metabolism
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Summary:IN this issue Martinet et al. 1 report that alveolar macrophages from patients with idiopathic pulmonary fibrosis release a growth-promoting activity similar to platelet-derived growth factor (PDGF), and show that the amount of this activity is four times greater than that of the PDGF-like activity released from alveolar macrophages from normal subjects. Assays of chemotaxis and growth-promoting activity established that the mitogen secreted from macrophages was active, and the identity of the secreted activity was suggested by receptor-competition assays and by blockade of its biologic activity with anti-PDGF serum. The results are important, correlating an increased level of a secreted growth . . .
Bibliography:SourceType-Scholarly Journals-1
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ObjectType-Editorial-2
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198707233170409