A Versatile Polymer Support Useful for Large-Scale Synthesis of DNA for Biomedical Applications

A suitably derivatized MercKogel R 1 as an efficient solid support for the large-scale synthesis of DNA for biomedical applications, is described. Partial hydrolysis of these polyvinylacetate resins with 0.5 M NaOH solution 1 at room temperature for 30-80 min. yielded carriers 1 that could be loaded...

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Bibliographic Details
Published inNucleosides & nucleotides Vol. 17; no. 9-11; pp. 1787 - 1792
Main Authors Jaisankar #, P., Hinz, M., Happ, E., Seliger, H.
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.09.1998
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Summary:A suitably derivatized MercKogel R 1 as an efficient solid support for the large-scale synthesis of DNA for biomedical applications, is described. Partial hydrolysis of these polyvinylacetate resins with 0.5 M NaOH solution 1 at room temperature for 30-80 min. yielded carriers 1 that could be loaded with 120, 150, 258, and 368 μmoles of nucleosides g −1 . At present a DAAD fellow in the University of Ulm, Section of Polymers, Germany.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319808004715