Design and Interpretation of Linkage and Association Studies on Osteoporosis

Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studie...

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Published inClinical reviews in bone and mineral metabolism Vol. 8; no. 2; pp. 60 - 67
Main Authors Xu, Ting, Cheng, Yu, Guo, Yan, Zhang, Lei, Pei, Yu-Fang, Redger, Kirk, Liu, Yong-Jun, Deng, Hong-Wen
Format Journal Article
LanguageEnglish
Published New York New York : Humana Press Inc 01.06.2010
Humana Press Inc
Subjects
Endocrinology
Gynecology
Internal Medicine
Medicine
Medicine & Public Health
Original Paper
Orthopedics
Rheumatology
Study design
Osteoporosis
Linkage
Association
Interpretation
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Summary:Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studies have been widely performed to test candidate genes for osteoporosis. In this article, we review the design and interpretation of linkage and association studies on osteoporosis.
Bibliography:http://dx.doi.org/10.1007/s12018-010-9070-6
ObjectType-Article-2
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ISSN:1534-8644
1559-0119
DOI:10.1007/s12018-010-9070-6