The aggregation-caused quenching effect and fluorescence enhancement features of ZIF-90 and their feasibility for the detection and imaging of ATP in cells

Herein, two new or overlooked features of ZIF-90 were identified and investigated. Imidazole-2-carboxaldehyde is fluorescent, but its fluorescence in ZIF-90 is quenched by an ACQ effect. ZIF-90 can enhance the fluorescence of Cy5, but quench that of 6-FAM. The applicability of the two newly identifi...

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Published inAnalyst (London) Vol. 15; no. 4; pp. 6 - 64
Main Authors Fu, Jing-Hao, Wang, Xuan, Xia, Qi-He, Chen, Zeng-Ping, Shen, Ping-Fan, Chen, Yao, Yu, Ru-Qin
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 10.02.2025
Subjects
Adenosine Triphosphate - analysis
Biosensing Techniques - methods
Carbocyanines - chemistry
Feasibility Studies
Fluorescence
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Imidazole
Imidazoles - chemistry
Metal-Organic Frameworks
Nanoparticles
Optical Imaging - methods
Spectrometry, Fluorescence - methods
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Summary:Herein, two new or overlooked features of ZIF-90 were identified and investigated. Imidazole-2-carboxaldehyde is fluorescent, but its fluorescence in ZIF-90 is quenched by an ACQ effect. ZIF-90 can enhance the fluorescence of Cy5, but quench that of 6-FAM. The applicability of the two newly identified features in biosensing was explored. Two new or overlooked features of ZIF-90 were identified, and successfully utilized to design fluorescence sensors for intracellular ATP imaging in living cells.
Bibliography:Electronic supplementary information (ESI) available. See DOI
https://doi.org/10.1039/d4an01385a
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0003-2654
1364-5528
1364-5528
DOI:10.1039/d4an01385a