Pediatric Thrombotic Events: Incidence, Clinical Risk Factors and Outcome

• Published in: Indian journal of pediatrics Vol. 86; no. 3; pp. 241 - 244
• Main Authors: Gupta, Tanay, Delhi Kumar, C. G., Ramesh Kumar, R., Adhisivam, B.
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.03.2019
• Subjects: Activated Protein C Resistance; Anticoagulants - therapeutic use; Antithrombin III; Child; Child, Preschool; Female; Gynecology; Heparin - therapeutic use; Heparin, Low-Molecular-Weight; Humans; Incidence; Infant; Male; Medicine; Medicine & Public Health; Original Article; Pediatrics; Prospective Studies; Risk Factors; Thrombosis - diagnosis; Thrombosis - drug therapy; Thrombosis - etiology; Treatment Outcome; Venous Thromboembolism; Venous Thrombosis; Warfarin - therapeutic use; Pediatrics; Thrombosis; Outcome; Risk factor; Incidence
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-018-2827-5

Objective To study the incidence, clinical risk factors and outcome of thrombotic events in pediatric age group of 1 mo-12 y. Methods This prospective observational study was conducted in a tertiary care institute from September 2015 through October 2017. Forty nine children with thrombosis from 1 mo-12 y were enrolled. Results Out of 49 cases, 30 (61.2%) were due to venous thromboembolism (VTE) and 19 (38.8%) were of arterial thromboembolism (ATE). The cumulative average annual incidence for VTEs was found to be 38.2 ( n  = 30) and for ATEs it was found to be 24.2 ( n  = 19) per 10,000 hospital admissions over 2 y of study period. With total of 19 (38.7%), catheters were the leading cause of thrombosis followed by infection numbering to 10 cases (20.4%). Total 42.8% cases ( n  = 21) achieved complete resolution. Partial resolution was noted in 53.2% of cases ( n  = 26) and no resolution in 4% cases ( n  = 2). Total seven (14.3%) deaths were recorded during the study period. Conclusions The present study showed that thrombosis is an emerging problem in tertiary care setting adding to both mortality and morbidity in children. Central venous catheters followed by infection were the leading cause of thrombosis in this study.