MOF confinement enables selective synthesis of novel oxazoles from indole and formaldehyde

Herein, we report the successful guidance of indole and formaldehyde reactivity by precisely tuning the pore size and active sites of MOF, altering their intrinsic reaction pathways. This led to the first example of novel compounds synthesized through the synergistic catalysis enabled by MOF confine...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 61; no. 12; pp. 252 - 2523
Main Authors Zheng, Deng-Yue, Gao, Jinping, Diao, Yue, Li, Mian, Huang, Xiao-Chun
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 04.02.2025
Royal Society of Chemistry
Subjects
Cascade chemical reactions
Chemical synthesis
Chemistry
Chemistry, Multidisciplinary
Confined spaces
Confinement
Formaldehyde
Physical Sciences
Pore size
Science & Technology
CATALYSIS
CONDENSATION
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Summary:Herein, we report the successful guidance of indole and formaldehyde reactivity by precisely tuning the pore size and active sites of MOF, altering their intrinsic reaction pathways. This led to the first example of novel compounds synthesized through the synergistic catalysis enabled by MOF confinement. Detailed mechanistic studies revealed that the confined environment within the MOF pores promoted the occurrence of multi-stage cascade reactions and stabilized specific reaction pathways. The high reactivity of indole and formaldehyde has been successfully controlled through the confinement effect of MOF, enabling the highly selective synthesis of novel oxazole compounds via a specific reaction pathway.
Bibliography:https://doi.org/10.1039/d4cc06486k
Electronic supplementary information (ESI) available. See DOI
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc06486k