Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi
Covering: up to December 2023 Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and an...
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| Published in | Natural product reports Vol. 41; no. 8; pp. 1294 - 1317 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
14.08.2024
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Covering: up to December 2023
Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure-activity relationship are then introduced.
Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. |
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| Bibliography: | Sang Hee Shim is a Professor in the Natural Products Research Institute, College of Pharmacy, at Seoul National University (SNU), Korea. She began her career as a post-doctor at the University of Iowa and the University of Illinois at Chicago after receiving her PhD from SNU in 2004. Then she started independent work at Yeungnam University in 2007 until she transferred to Duksung Women's University in 2015. In 2021, she joined SNU as a professor. Her research group mainly focuses on discovery of bioactive compounds from endosymbiotic microorganisms. She has published over 100 SCI(E) research papers as of 2024. Hyunwoo Kim has been an Assistant Professor at the College of Pharmacy, Dongguk University since 2022. He received his BS in Pharmacy in 2012 from Seoul National University. In 2018, he obtained his PhD in pharmacognosy under the guidance of the late Prof. Sang Hyun Sung at the same university. In 2019, he moved to the Scripps Institution of Oceanography for a postdoctoral position with William H. Gerwick, where he developed artificial intelligence to accelerate natural product research. His research interests focus on the combination of natural product chemistry and cheminformatics for efficient drug discovery from natural products. Jin Woo Lee is an Assistant Professor at the College of Pharmacy at Duksung Women's University (2022-present). He obtained his BS (2009), MS (2011), and PhD (2016) degrees from the College of Pharmacy of Chungbuk National University with a major in Pharmacognosy and Natural Products Chemistry. He worked as a Post-doctoral Researcher at the Department of Chemistry and Biochemistry of the University of Oklahoma (2017-2022). He has been working as a faculty at College of Pharmacy, Duksung Women's University since 2022. His current research mainly focuses on finding novel molecules from soil fungi collected from diverse or unique soil samples. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0265-0568 1460-4752 1460-4752 |
| DOI: | 10.1039/d4np00013g |