HLA-A1, B8-phenotype association and HBs antigenemia evolution in 440 hemodialyzed patients

HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HL-A-A1, B8 association (18.6%) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population...

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Bibliographic Details
Published inDigestion Vol. 15; no. 4; p. 271
Main Authors Descamps, B, Jungers, P, Naret, C, Degott, C, Zingraff, J, Bach, J F
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1977
Subjects
Chronic Disease
Epitopes
Follow-Up Studies
Hepatitis - immunology
Hepatitis B Antigens - analysis
Hepatitis, Viral, Human - immunology
Histocompatibility Antigens - analysis
HLA Antigens - analysis
Humans
Phenotype
Renal Dialysis
Uremia - immunology
Uremia - therapy
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Summary:HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HL-A-A1, B8 association (18.6%) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population (5.05%, p less than 10(-4), and with the group of patients unable to eliminate HBsAg (7.0%, less than 0.01). Chronic aggressive hepatitis was only found in the latter. This high frequency of the HLA-A1, B8 association has also been found in patients with seronegative active chronic hepatitis and suggests that this phenotype might be associated with high immune response against HBsAg.
ISSN:0012-2823
DOI:10.1159/000198012