Structural trees for proteins containing φ-motifs
In the present study, a novel structural motif of proteins referred to as the φ-motif is considered, and two novel structural trees in which the φ-motif is taken as the root structure have been constructed. The simplest φ-motif is formed by three adjacent β-strands connected by loops and packed in o...
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Published in | Biochemistry (Moscow) Vol. 73; no. 1; pp. 23 - 28 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Dordrecht : SP MAIK Nauka/Interperiodica
2008
SP MAIK Nauka/Interperiodica |
Subjects | |
Online Access | Get full text |
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Summary: | In the present study, a novel structural motif of proteins referred to as the φ-motif is considered, and two novel structural trees in which the φ-motif is taken as the root structure have been constructed. The simplest φ-motif is formed by three adjacent β-strands connected by loops and packed in one β-sheet so that its overall fold resembles the Greek letter φ. Construction of the structural trees and modeling of folding pathways have shown that all structures of the protein superfamilies can be obtained by stepwise addition of α-helices and/or β-strands to the root φ-motif taking into account a restricted set of rules inferred from known principles of protein structure. The structural trees are a good tool for structure comparison, structural classification of proteins, as well as for searching for all possible protein folds and folding pathways. |
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Bibliography: | http://dx.doi.org/10.1134/S0006297908010033 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-2979 1608-3040 |
DOI: | 10.1134/S0006297908010033 |