Lewis acid catalyzed highly selective halogenation of aromatic compounds

A simple and efficient procedure for the halogenation of aromatic compounds with NCS, NBS, NIS and NFSI in the presence of catalytic amount of ZrCl4 is described. Chlorination, bromination, iodination and fluorination of various aromatic compounds are performed with high selectivity under mild react...

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Bibliographic Details
Published inSynlett no. 18; pp. 2837 - 2842
Main Authors Zhang, YH, Shibatomi, K, Yamamoto, H
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 03.11.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BROMINATION
N-halo reagents
aromatic compounds
zirconium tetrachloride
IODINATION
halogenation
Lewis acid catalysis
EFFICIENT
N-IODOSUCCINIMIDE
CHLORINATION
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Summary:A simple and efficient procedure for the halogenation of aromatic compounds with NCS, NBS, NIS and NFSI in the presence of catalytic amount of ZrCl4 is described. Chlorination, bromination, iodination and fluorination of various aromatic compounds are performed with high selectivity under mild reaction conditions.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-918919