Preparation and characterization of a new hydrophilic C60 derivative (OH)16C60CHCOOH

• Published in: Journal of nanoscience and nanotechnology Vol. 10; no. 2; p. 927
• Main Authors: Zhu, Engao, Liu, Ruili, Lv, Min, Li, Qingnuan, Li, Wenxin, Zhao, Yun, Huang, Qing
• Format: Journal Article
• Language: English
• Published: United States 01.02.2010
• Subjects: Cell Line; Cell Survival; Electron Spin Resonance Spectroscopy; Free Radical Scavengers - chemistry; Fullerenes - chemistry; Humans; Hydroxyl Radical - chemistry; Models, Molecular
• ISSN: 1533-4880
• DOI: 10.1166/jnn.2010.1878

C60 and its derivatives are very important nanomaterials in biological and materials science. Unfortunately, due to the high hydrophobicity of the C60 cage, most of these materials are insoluble in water and their usages are quitely restricted. Here we reported the preparation and characterization of (OH)16C60CHCOOH, a new multihydroxylated methanofullerene carboxylic acid (MMFCA) derivative with high aqueous solubility. The elementary analysis, FT-IR and 1HNMR confirmed the structure of this material. Like other C60 and its derivatives, this new derivative also contains the free radical scavenging ability, measured by electron spin resonance (ESR) test. On the other hand, the MTT assay showed it had low cytotoxicity. Therefore, this new MMFCA derivative might be a potential vehicle for the introduction of hydrophobic C60 derivatives into water or a hydrophilic environment.