Physical status of human papillomavirus in the prognosis of recurrence of low-grade and-high-grade cervical intraepithelial lesions

• Published in: Sibirskiĭ onkologicheskiĭ zhurnal Vol. 17; no. 6; pp. 70 - 77
• Main Authors: Ibragimova, M. K., Churuksaeva, O. N., Bychkov, V. A., Tsyganov, M. M., Deryusheva, I. V., Shpileva, O. V., Kolomiets, L. A., Litviakov, N. V.
• Format: Journal Article
• Language: English; Russian
• Published: Russian Academy of Sciences, Tomsk National Research Medical Center 01.01.2019
• Subjects: cervix; cin; hsil; human papillomavirus; integrated and episomal forms of hpv; lsil; oncogenic viruses; physical status of the virus; prognostic factor; survival; viral load
• ISSN: 1814-4861; 2312-3168
• DOI: 10.21294/1814-4861-2018-17-6-70-77

The study included 168 patients with precancerous cervical lesions 37 with low-grade squamous intraepithelial lesions (LSIL), 131 with high-grade squamous intraepithelial lesions (HSIL), and 150 women, who had not abnormal cervical cell changes. All patients underwent full colposcopy assessment, cytological/histological examination, molecular detection and genotyping of high-risk human papillomavirus. Viral load and physical status of HPV-16 DNA was evaluated in cases of mono-infection (n=208). The prevalence of virus-positive cases among the patients with LSIL/NSIL and healthy women was 78.5 and 50.7 %, respectively. The frequency of recurrence in patients with LSIL and HSIL was found to be determined by the physical status of HPV-16. A significant difference in episomal, mixed and integrated forms of HPV-16 between patients with LSIL/HSIL and patients without abnormal cervical cell changes was found (p=0.0002).