Outbreak of co-trimoxazole- and gentamicin-resistant Klebsiella aerogenes bacteremia in neutropenic patients receiving oral co-trimoxazole prophylaxis

Over a five-day period, three neutropenic patients developed bacteremia with an identical strain of Klebsiella aerogenes (serotype K16) resistant to co-trimoxazole and gentamicin. All three patients had received prophylaxis with oral co-trimoxazole before the onset of bacteremia. This report outline...

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Bibliographic Details
Published inAustralian and New Zealand journal of medicine Vol. 13; no. 6; p. 636
Main Authors Leahy, M F, Humble, M W
Format Journal Article
LanguageEnglish
Published Australia 01.12.1983
Subjects
Aged
Drug Combinations - therapeutic use
Drug Resistance, Microbial
Drug Therapy, Combination
Female
Gentamicins - therapeutic use
Humans
Klebsiella Infections - drug therapy
Klebsiella pneumoniae - drug effects
Male
Middle Aged
Neutropenia - complications
Sepsis - drug therapy
Sulfamethoxazole - therapeutic use
Trimethoprim - therapeutic use
Trimethoprim, Sulfamethoxazole Drug Combination
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Summary:Over a five-day period, three neutropenic patients developed bacteremia with an identical strain of Klebsiella aerogenes (serotype K16) resistant to co-trimoxazole and gentamicin. All three patients had received prophylaxis with oral co-trimoxazole before the onset of bacteremia. This report outlines some of the problems associated with co-trimoxazole prophylaxis.
ISSN:0004-8291
DOI:10.1111/j.1445-5994.1983.tb02621.x