A nonparametric mixture approach to density and null proportion estimation in large‐scale multiple comparison problems

• Published in: Australian & New Zealand journal of statistics Vol. 65; no. 1; pp. 49 - 75
• Main Authors: Xue, Xiangjie, Wang, Yong
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.03.2023
• Subjects: consistent estimation; Density; Likelihood ratio; Maximum likelihood estimation; Maximum likelihood estimators; mixture distribution; Mixtures; multiple hypothesis testing; nonparametric mixture; Nonparametric statistics; null effects; profile likelihood; Scale (ratio); Statistical tests
• ISSN: 1369-1473; 1467-842X
• DOI: 10.1111/anzs.12383

Summary A new method for estimating the proportion of null effects is proposed for solving large‐scale multiple comparison problems. It utilises maximum likelihood estimation of nonparametric mixtures, which also provides a density estimate of the test statistics. It overcomes the problem of the usual nonparametric maximum likelihood estimator that cannot produce a positive probability at the location of null effects in the process of estimating nonparametrically a mixing distribution. The profile likelihood is further used to help produce a range of null proportion values, corresponding to which the density estimates are all consistent. With a proper choice of a threshold function on the profile likelihood ratio, the upper endpoint of this range can be shown to be a consistent estimator of the null proportion. Numerical studies show that the proposed method has an apparently convergent trend in all cases studied and performs favourably when compared with existing methods in the literature.