Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures
The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different anesthetics act at different molecular targets and neural circuits to produce dist...
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Published in | Anesthesiology (Philadelphia) Vol. 123; no. 4; pp. 937 - 960 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Copyright by , the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc
01.10.2015
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Subjects | |
Online Access | Get full text |
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Summary: | The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different anesthetics act at different molecular targets and neural circuits to produce distinct brain states that are readily visible in the electroencephalogram. We present a two-part review to educate anesthesiologists on use of the unprocessed electroencephalogram and its spectrogram to track the brain states of patients receiving anesthesia care. Here in part I, we review the biophysics of the electroencephalogram and the neurophysiology of the electroencephalogram signatures of three intravenous anestheticspropofol, dexmedetomidine, and ketamine, and four inhaled anestheticssevoflurane, isoflurane, desflurane, and nitrous oxide. Later in part II, we discuss patient management using these electroencephalogram signatures. Use of these electroencephalogram signatures suggests a neurophysiologically based paradigm for brain state monitoring of patients receiving anesthesia care. |
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Bibliography: | DEPARTMENT AND INSTITUTION Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts |
ISSN: | 0003-3022 1528-1175 |
DOI: | 10.1097/ALN.0000000000000841 |