Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics

Staphylococcus aureus uses small peptides to assess its population densisty (i.e., quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specific...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 5; pp. 587 - 590
Main Authors Zhao, Ke, Vasquez, Joseph K., Blackwell, Helen E.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 12.01.2023
Royal Society of Chemistry
Subjects
Bacterial Proteins - metabolism
Chemistry
Chemistry, Multidisciplinary
Humans
Peptides
Peptides - metabolism
Peptidomimetics - metabolism
Peptidomimetics - pharmacology
Physical Sciences
Quorum Sensing
Science & Technology
Staphylococcal Infections
Staphylococcus aureus - physiology
RECEPTOR
AUTOINDUCING PEPTIDES
ACTIVATION
VIRULENCE
ANALOGS
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Summary:Staphylococcus aureus uses small peptides to assess its population densisty (i.e., quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc05733f