Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics

• Published in: Food Science and Human Wellness Vol. 13; no. 2; pp. 721 - 728
• Main Authors: Yang, Lan, Kwok, Lai-Yu, Sun, Zhihong, Zhang, Heping
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2024
• Subjects: Gut microbiome; Infant; Lacticaseibacillus rhamnosus; Metagenomic analysis; Mother; Metagenomic analysis; Infant; Lacticaseibacillus rhamnosus; Mother; Gut microbiome
• ISSN: 2213-4530; 2097-0765; 2213-4530
• DOI: 10.26599/FSHW.2022.9250061

Probiotics exert beneficial effects on the host. This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut. This study recruited one pregnant woman, who ingested Probio-M9 daily from 35 weeks of gestation to delivery. Feces of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant’s age for metagenomic sequencing. Probio-M9 genomes were mappable to all infant fecal samples, suggesting the ingested probiotics could be vertically transmitted from mother to infant. Infant- or mother-specific differential metabolic pathways were found between the maternal and infant’s gut microbiome, implicating apparent differences in the intestinal metagenomic potential/function between the mother and the infant. In conclusion, maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant gut. The findings provided novel insights into shaping infant’s gut microbiota. [Display omitted] •Gut microbiome is related to health. How to shape the gut microbiome is tempting.•Probiotics is helpful to host. It is significant to deliver probiotics to infant.•This study showed L. rhamnosus Probio-M9 could transmit from mother to infant.•The findings provided novel insights into ways of shaping infant’s gut microbiota.