Predictors of High Sputum Eosinophils in COPD
Background: Eosinophils are involved in the development of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroid responsiveness. We evaluated clinical predictors of high sputum eosinophil levels in a COPD cohort in China. Methods: We conducted an observational, prospective, populat...
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| Published in | Chronic obstructive pulmonary diseases Vol. 9; no. 3; pp. 413 - 426 |
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| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Miami, USA
COPD Foundation Inc
01.01.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Background:
Eosinophils are involved in the development of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroid responsiveness. We evaluated clinical predictors of high sputum eosinophil levels in a COPD cohort in China.
Methods:
We conducted an observational, prospective, population-based, cross-sectional study. Participants were tested for COPD and underwent spirometry, computed tomography scans, and a blood test. Participants also produced induced sputum and responded to an information-gathering questionnaire. High sputum eosinophils were defined as ≥3.0%. Multivariate logistic regression was used to identify predictors of high sputum eosinophil levels.
Results:
We recruited 895 patients with complete and quality control data. The median percentage of sputum eosinophil abundance was 2.00% (interquartile range: 0.75–5.00) and the prevalence of COPD with high sputum eosinophils was 38.0%. Covariance analysis indicated that the high sputum eosinophil group had lower lung function, more severe emphysema, and air trapping. Multivariate logistic regression indicated that high blood eosinophil levels, severe respiratory symptoms, being a former smoker, and a family history of respiratory diseases were associated with high sputum eosinophil levels.
Conclusion:
High blood eosinophil levels, severe respiratory symptoms, being a former smoker, and a family history of respiratory diseases may be predictors of high sputum eosinophil levels in Chinese COPD patients. High sputum eosinophils were associated with lower lung function, more emphysema, and gas trapping. |
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| Bibliography: | All authors declare no conflicts of interest. We thank all participants who have consented to include their data for analysis. We thank the medical staff of the First Affiliated Hospital of Guangzhou Medical University, Lianping County People’s Hospital (Xiangwen Luo and Shuqing Yu), and Wengyuan County People’s Hospital (Changli Yang) for their assistance in conducting this study. We thank Bijia Lin, Shaodan Wei, Xiaopeng Lin, Wenjun Lai, Qiaoyi He, and Yunsong Chen (Nanshan Medical Development Foundation of Guangdong Province, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University) for their efforts in collecting the information and verification. We thank Liwen Bianji (Edanz) for editing the English text of a draft of this manuscript. Author contributions: YMZ, PXR, XW, JQP, and YLZ designed the project, planned the statistical analysis, and drafted and revised the paper. XW, JQP, YLZ, JXL, HST, FW, ZHW, HJY, ZSD, SX, PYH, JWX, CQD, NNZ, LFL, JWD, and BL collected and monitored the data collection. All authors approved the final draft of the manuscript for publication. PXR and YMZ are the study guarantors. The authors were accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Data sharing statement: Unpublished data is available upon request by contacting the corresponding author. |
| ISSN: | 2372-952X 2372-952X |
| DOI: | 10.15326/jcopdf.2022.0310 |